Direct [ 11 C]Methylation of Amines from [11C]CO 2 for the Synthesis of PET Radiotracers

11 C-Methylation (t1/2 = 20.4 min) is a main labeling strategy in the development of PET radiotracers. A straight radiomethylation of amines by use of cyclotron-produced 11 CO2 was developed to obtain various radiolabeled compounds with good radiochemical yields. This strategy constitutes a new approach to simplify the radiolabeling processes and transpositions onto automatic synthesizers. This method was applied to the syntheses of radiolabeled drugs and a PET radiotracer used in Alzheimer's disease studies.

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Chimie organique

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Thierry Billard : Connectez-vous pour contacter le contributeur

https://hal.science/hal-03719209

Soumis le : lundi 11 juillet 2022-08:58:10

Dernière modification le : mercredi 18 décembre 2024-10:13:29

Archivage à long terme le : mercredi 12 octobre 2022-18:11:27

Dates et versions

hal-03719209 , version 1 (11-07-2022)

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HAL Id : hal-03719209 , version 1
DOI : 10.1002/ejoc.201500924

Citer

François Liger, Ture Eijsbouts, Florence Cadarossanesaib, Christian Tourvieille, Didier Le Bars, et al.. Direct [ 11 C]Methylation of Amines from [11C]CO 2 for the Synthesis of PET Radiotracers. European Journal of Organic Chemistry, 2015, 2015 (29), pp.6434-6438. ⟨10.1002/ejoc.201500924⟩. ⟨hal-03719209⟩

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