Background: Each year in Europe, nearly 24,000 patients, adults and children of all ages, are transplanted, the last resort to treat and potentially cure serious blood diseases. While this intervention is saving more and more lives, it can lead to early or late complications in 50% of patients, very disabling in every day life and fatal in 25% of cases. Therefore, the chances of a successful transplant for these patients correlate directly with the non-occurrence of these complications. Recently, research in the field of transplantation and in particular psycho-neuro-immunology has highlighted the mutual influence of psychological and physical health on the chances of successful transplantation. Indeed, the simultaneous management of the mind and body of the patient would ensure better preparation for the transplant process for faster recovery after it by limiting the occurrence of complications. The establishment of an overall well-being throughout the transplant process, based on three inseparable pillars - nutritional, physical and psychological -, would contribute to very significantly increase the success of the transplant and the chances of recovery of the patient. Methods: Currently, there is limited comprehensive support program in the field of transplantation, based on clinical data and patient quality of life that can help them overcome the difficulties of preparing for transplant, the period of hospitalization in a protected environment as well as those related to the return to social and professional life. To answer patients’needs in terms of health support and quality of life improvement, the HTC Project has initiated the development of the digital solution NewSpringForMe. This tool intend to bring complementary therapeutic support for care, reinforcing it, and making each patient the main player in their quality of life. Results: The innovation of NewSpringForMe lies in the simultaneous management of transplanted patients in three dimensions: psychology, nutrition and physical activity. Designed around interconnected spaces, NewSpringForMe deploys recommendations, interactive tools and exercises adapted to respond to 1) each patient and their specific situation, 2) the different phases of their transplant protocol. NewSpringForMe aims at a better preparation and a more global care of the patient, condition of the best live towards its remission. A clinical study, in collaboration with the St Louis Hospital (AP-HP), is scheduled at the early 2022 in order to measure the impact of NewSpringForMe use on the psychological (ex. affect levels), nutritional (ex. level and quality of appetite) and physical (ex. effort and suppleness) parameters of almost 170 patients during one year. This study would also evaluate the impact on the post-transplant complications onset and the post-transplant recovery. The clinical study will be performed in accordance with the regulatory prerequisites. Conclusions: The data collected during the clinical protocol directly from the patients’experience will help in NewSpringForMe evaluation as a global support. A positive impact should be expected on patients daily quality of life, on the appearance of the post-transplant complications and the number of treatments. If this pilot phase is a success, NewSpringForMe could be proposed to the all French transplant units in order to lead a large-scale study.