We consider a linear symmetric operator in a Hilbert space that is neither bounded from above nor from below, admits a block decomposition corresponding to an orthogonal splitting of the Hilbert space and has a variational gap property associated with the block decomposition. A typical example is the minimal Dirac-Coulomb operator defined on C ∞ c (R 3 \{0}, C 4). In this paper we define a distinguished self-adjoint extension with a spectral gap and characterize its eigenvalues in that gap by a variational min-max principle. This has been done in the past under technical conditions. Here we use a different, geometric strategy, to achieve that by making only minimal assumptions. Our result applied to the Dirac-Coulomb-like Hamitonians covers sign-changing potentials as well as molecules with an arbitrary number of nuclei having atomic numbers less than or equal to 137.