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Journal Articles Optics Continuum Year : 2022

Scanning point terahertz source microscopy of unstained comedo ductal carcinoma in situ

Abstract

Terahertz imaging is an emerging candidate to diagnose breast cancers in a labelfree manner. However, detailed terahertz analysis of early stage breast cancers is difficult to achieve owing to its low spatial resolution. In this study, utilizing a probe-less terahertz near-field microscope named scanning point terahertz source microscope, we visualize an unstained comedo ductal-carcinoma-in-situ including an architectural structure (comedo necrosis) measuring ∼ϕ500 μm, which is known as highly-malignant early-stage breast cancer, in terahertz images for the first time. The outcome is a critical step toward the label-free diagnosis of single early stage cancer lesions with terahertz waves.
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hal-03691895 , version 1 (09-06-2022)

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Kosuke Okada, Quentin Cassar, Hironaru Murakami, Gaëtan Macgrogan, Jean Paul Guillet, et al.. Scanning point terahertz source microscopy of unstained comedo ductal carcinoma in situ. Optics Continuum , 2022, 1 (3), pp.527-537. ⟨10.1364/OPTCON.448444⟩. ⟨hal-03691895⟩
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