Based on existing studies that examine telework as flexible, nonstandard or unconventional working arrangements (Marler et al., 2002; Lambert et al., 2008; Berkery et al., 2017), this paper adopts a spatiotemporal perspective and defines telework as spatiotemporal arrangements, supported or constructed by digital actants, for realizing professional activities. It identifies the specific characteristics of wellbeing at work when work transits from traditional office-based environment to teleworking environment, and proposes a spatiotemporal model of wellbeing at telework in which the temporal dimension and spatial dimension (Cumming et al., 2009; Sewell & Taskin, 2015; Aristidou & Barrett, 2018) are intrinsically synchronized at and around work. The paper next exposes the HRM, notably e-HRM implications of this analysis by formulating three propositions, and ends by discussing the interest and limitations of the spatiotemporal perspective for studying wellbeing at telework.