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Article Dans Une Revue Materials & Design Année : 2022

Leistungsstarke, additiv hergestellte Knochengerüste auf der Basis von kupfersubstituiertem Diopsid

High performing additively manufactured bone scaffolds based on copper substituted diopside

Échafaudages osseux de haute performance fabriqués de manière additive à base de diopside substitué par du cuivre

Résumé

The inclusion of small amounts of copper is often reported to enhance the mechanical and biointegrative performance of bioceramics towards tissue engineering applications. In this work, 3D scaffolds were additively manufactured by robocasting of precipitation derived copper doped diopside. Compositions were chosen in which magnesium sites in diopside were substituted by copper up to 3 at.%. Microstructure, mechanical performance, bioactivity, biodegradability, drug release, biocompatibility, in vitro angiogenesis and antibacterial activity were studied. Results indicate that copper is incorporated in the diopside structure and improves materials’ fracture toughness. Scaffolds with > 80% porosity exhibited compressive strengths exceeding that of cancellous bone. All compositions showed bioactivity and drug release functionalities. However, only samples with 0–1 at.% copper substitution showed favorable proliferation of osteogenic sarcoma cells, human umbilical vein endothelial cells and fibroblasts, while larger amounts of copper had cytotoxic behavior. In vitro angiogenesis was significantly enhanced by low levels of copper. Copper-containing materials showed anti-Escherichia coli activity, increasing with copper content. We show that across multiple indicators, copper substituted diopside of the composition CaMg0.99Cu0.01Si2O6, exhibits high performance as a synthetic bone substitute, comparing favorably with known bioceramics. These findings present a pathway for the enhancement of bioactivity and mechanical performance in printable bioceramics.
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Dates et versions

hal-03675912 , version 1 (23-05-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Shumin Pang, Dongwei Wu, Franz Kamutzki, Jens Kurreck, Aleksander Gurlo, et al.. High performing additively manufactured bone scaffolds based on copper substituted diopside. Materials & Design, 2022, 215, pp.110480. ⟨10.1016/j.matdes.2022.110480⟩. ⟨hal-03675912⟩
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