Boundary feedback control design is studied for 1D hyperbolic systems with an in-domain disturbance and a boundary feedback controller under the effect of actuator saturation. Nonlinear semigroup theory is used to prove well-posedness of mild solution pairs to the closed-loop system. Sufficient conditions in the form of dissipation functional inequalities are derived to establish global stability for the closed-loop system and -stability in presence of in-domain disturbances. The control design problem is then recast as an optimization problem over linear matrix inequality constraints. Numerical results are shown to validate the effectiveness of the proposed control design.