Introduction: Safety-critical fields such as Air Traffic Control address safety during the design stage by applying task-modeling techniques, and human error prediction of knowledge-based, skill-based and rule-based mistakes and lapses [3]. However, the cooperative nature of the activity is not the primary focus in these approaches. Rather, it is the behavioral or cognitive errors that occur. Medical services are cooperative activities that involve a number of participants (e.g.physician, nurse, technologist, pharmacist, etc.) who work towards a common goal of providing healthcare. Clinical activity is not only a highly cooperative process, but also safety-critical, collaborative, distributed over time and space, and characterized by high complexity and coordination demands. Communication enables the cooperation, collaboration, and coordination processes [1], and eHealth technology mediates these processes. What, then, are the implications of a communication breakdown? Technology represents the backbone of the healthcare process. However, it is medical professionals who assume responsibility for the failures of technology [2]. The discussion of human factors in medicine centers on accreditation, licensure, a posteriori analysis of accidents, and decision-making. We propose an adverse-event minded design method for eHealth applications that considers the error-prone nature of the distributed computer-supported medical work process. We model potential breakdowns, afforded by the medium, the task, and the workflow. Our method can account for potential failures and suggest design and workflow solutions to prevent accidents, a priori.