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Article Dans Une Revue Scientific Reports Année : 2016

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

Résumé

Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we showed that amicoumacin A inhibits translation in yeast and mammalian systems by affecting translation elongation. We determined the structure of the amicoumacin A complex with yeast ribosomes at a resolution of 3.1 Å. Toxicity measurement demonstrated that human cancer cell lines are more susceptible to the inhibition by this compound as compared to non-cancerous ones. This might be used as a starting point to develop amicoumacin A derivatives with clinical value.

Dates et versions

hal-03661134 , version 1 (06-05-2022)

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Irina Prokhorova, Kseniya Akulich, Desislava Makeeva, Ilya Osterman, Dmitry Skvortsov, et al.. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Scientific Reports, 2016, 6 (1), pp.27720. ⟨10.1038/srep27720⟩. ⟨hal-03661134⟩
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