Journal Articles Organic & Biomolecular Chemistry Year : 2022

β-Lactam and penicillin substituted mesoionic metal carbene complexes

Abstract

1,2,3-Triazolylidene MIC M-complexes (M = Au, Pd, Pt) having 2-azetidinones and penicillin G substituents at the triazole ring were prepared by CuAAC on 2-azetidinones having a terminal alkyne tethered at N1, followed by alkylation of the 1,2,3-triazole ring and transmetallation [Au(I), Pd(II) and Pt(II)]. The Au–MIC complexes efficiently catalyze the regioselective cycloisomerization of enynes, while the Pt–MIC complexes were efficient catalysts in hydrosilylation reactions.
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Dates and versions

hal-03660770 , version 1 (10-10-2022)

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Marta Avello, María Moreno-Latorre, María C. de La Torre, Luis Casarrubios, Heinz Gornitzka, et al.. β-Lactam and penicillin substituted mesoionic metal carbene complexes. Organic & Biomolecular Chemistry, 2022, 20 (13), pp.2651-2660. ⟨10.1039/D2OB00216G⟩. ⟨hal-03660770⟩
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