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Article Dans Une Revue European Journal of Organic Chemistry Année : 2022

Sustainable Mechanosynthesis of Biologically Active Molecules

Résumé

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities of all kinds. This Review is focused on examples reported so far of known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, all prepared by mechanosynthesis. Three families of molecules are discussed: heterocyclic compounds, metal complexes and peptides. Advantages of the mechanochemistry approach are highlighted especially from a green chemistry and efficacy point of view.
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hal-03648217 , version 1 (22-04-2022)
hal-03648217 , version 2 (22-08-2022)

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Ophélie Bento, Florian Luttringer, Tharwat Mohy El Dine, Nicolas Pétry, Xavier Bantreil, et al.. Sustainable Mechanosynthesis of Biologically Active Molecules. European Journal of Organic Chemistry, In press, ⟨10.1002/ejoc.202101516⟩. ⟨hal-03648217v1⟩
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