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Article Dans Une Revue European Journal of Nutrition Année : 2022

Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats

Résumé

Physiological parameters such as adiposity and age are likely to infuence protein digestion and utilization. The aim of this study was to evaluate the combined efects of age and adiposity on casein protein and amino acid true digestibility and its postprandial utilization in rats Four groups were included (n=7/8): 2 months/normal adiposity, 2 months/high adiposity, 11 months/normal adiposity and 11 months/high adiposity. Rats were given a calibrated meal containing 15N-labeled casein (Ingredia, Arras, France) and were euthanized 6 h later. Digestive contents were collected to assess protein and amino acid digestibilities. 15N enrichments were measured in plasma and urine to determine total body deamination. Fractional protein synthesis rate (FSR) was determined in diferent organs using a fooding dose of 13C valine. Nitrogen and amino acid true digestibility of casein was around 95–96% depending on the group and was increased by 1% in high adiposity rats (P=0.04). Higher adiposity levels counteracted the increase in total body deamination (P=0.03) that was associated with older age. Signifcant efects of age (P=0.006) and adiposity (P=0.002) were observed in the muscle FSR, with age decreasing it and adiposity increasing it. This study revealed that a higher level of adiposity resulted in a slight increase in protein and individual amino acid true digestibility values and seemed to compensate for the metabolic postprandial protein alterations observed at older age.
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Dates et versions

hal-03647308 , version 1 (13-09-2023)

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Nathalie Atallah, Claire C. Gaudichon, Audrey Boulier, Alain Baniel, Dalila Azzout-Marniche, et al.. Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats. European Journal of Nutrition, 2022, ⟨10.1007/s00394-022-02881-4⟩. ⟨hal-03647308⟩
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