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Article Dans Une Revue Cells Année : 2022

Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease

Résumé

Intrastriatal embryonic ventral mesencephalon grafts have been shown to integrate, survive,and reinnervate the host striatum in clinical settings and in animal models of Parkinson’s disease.However, this ectopic location does not restore the physiological loops of the nigrostriatal pathwayand promotes only moderate behavioral benefits. Here, we performed a direct comparison of thepotential benefits of intranigral versus intrastriatal grafts in animal models of Parkinson’s disease.We report that intranigral grafts promoted better survival of dopaminergic neurons and that onlyintranigral grafts induced recovery of fine motor skills and normalized cortico-striatal responses.The increase in the number of toxic activated glial cells in host tissue surrounding the intrastriatalgraft, as well as within the graft, may be one of the causes of the increased cell death observed in theintrastriatal graft. Homotopic localization of the graft and the subsequent physiological cell rewiringof the basal ganglia may be a key factor in successful and beneficial cell transplantation procedures.

Domaines

Neurobiologie
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Dates et versions

hal-03637153 , version 1 (01-07-2024)

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Marine Droguerre, Sébastien Brot, Clément Vitrac, Marianne Benoit-Marand, Laure Belnoue, et al.. Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease. Cells, 2022, 11 (7), ⟨10.3390/cells11071191⟩. ⟨hal-03637153⟩
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