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Article Dans Une Revue Microbes and Infection Année : 2022

Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii

Résumé

Toxoplasma gondii infects approximately 1-2 billion people, and manipulation of the macrophage response is critical to host and parasite survival. A cleaved (cl)-CD95L form can promote cellular migration and we have previously shown that cl-CD95L aggravates inflammation and pathology in systemic lupus erythematosus (SLE). Findings have shown that CD95L is upregulated during human infection, therefore we examined the effect of cl-CD95L on the macrophage response to T. gondii. . We find that cl-CD95L promotes parasite replication in macrophages, associated with increased arginase-1 levels, mediated by signal transducer and activator of transcription (STAT)6. Inhibition of both arginase-1 and STAT6 reversed the effects of cl-CD95L. Phospho-kinase array showed that cl-CD95L alters Janus Kinases (JAK)/STAT, mammalian target of rapamycin (mTOR), and Src kinase signals. By triggering changes in JAK/STAT cl-CD95L may limit anti-parasite effectors.
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hal-03632273 , version 1 (12-04-2022)

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Paternité - Pas d'utilisation commerciale

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Ellen A Tiffney, Janine L Coombes, Patrick Legembre, Robin J Flynn. Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii. Microbes and Infection, 2022, 24 (5), pp.104952. ⟨10.1016/j.micinf.2022.104952⟩. ⟨hal-03632273⟩
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