In this article we formulate several conjectures concerning the lowest eigenvalue of a Dirac operator with an external electrostatic potential. The latter describes a relativistic quantum electron moving in the field of some (pointwise or extended) nuclei. The main question we ask is whether the eigenvalue is minimal when the nuclear charge is concentrated at one single point. This well-known property in nonrelativistic quantum mechanics has escaped all attempts of proof in the relativistic case.