Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2002

Cellular localisation of a water-soluble fullerene derivative

Colin Crowley
  • Fonction : Auteur
Monique Smaihi
  • Fonction : Auteur
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Claude Bonfils
  • Fonction : Auteur
Bernard Erlanger
  • Fonction : Auteur
Patrick Seta
  • Fonction : Auteur
Christian Larroque

Résumé

Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclear. In this work, we have demonstrated that a fullerene derivative could cross the external cellular membrane and it localises preferentially to the mitochondria. We propose that our finding supports the potential use of fullerenes as drug delivery agents as their structure mimics that of clathrin known to mediate endocytosis.

Dates et versions

hal-03607885 , version 1 (17-10-2024)

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Citer

Sarah Foley, Colin Crowley, Monique Smaihi, Claude Bonfils, Bernard Erlanger, et al.. Cellular localisation of a water-soluble fullerene derivative. Biochemical and Biophysical Research Communications, 2002, 294, pp.116 - 119. ⟨10.1016/s0006-291x(02)00445-x⟩. ⟨hal-03607885⟩

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