On the structural origin of the anisotropy in the myocardium: Multiscale modeling and analysis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the mechanical behavior of biomedical materials Année : 2022

On the structural origin of the anisotropy in the myocardium: Multiscale modeling and analysis

Résumé

Due to structural heterogeneities within the tissue, the myocardium displays an orthotropic material behavior. However, the link between the microstructure and the macroscopic mechanical properties is still not fully established. In particular, if it is admitted that the cardiomyocyte organization induces a transversely isotropic symmetry, the relative role in the observed orthotropic symmetry of cardiomyocyte orientation variation and perimysium collagen "sheetlet" structure, two mechanisms occurring at different scales, is still a matter of debate. In order to shed light on this question, we designed a multiscale model of the myocardium, bridging the cell, sheetlet and tissue scales. More precisely, we compared the macroscopic anisotropy obtained by homogenization of different mesostructures consisting in cardiomyocytes and extracellular collageneous layers, also taking into account the variation of cardiomyocyte and sheetlet orientations on the macroscale, to available experimental data. This study confirms the importance of sheetlets layers in assuring the tissue's anisotropic response, as cardiomyocytes-only mesostructures cannot reproduce the observed anisotropy. Moreover, our model shows the existence of a size effect in the myocardial tissue shear properties, which will require further experimental analysis.
Fichier principal
Vignette du fichier
micro_model.pdf (2.17 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03604234 , version 1 (10-03-2022)

Identifiants

  • HAL Id : hal-03604234 , version 1

Citer

Nicole Tueni, Jean-Marc Allain, Martin Genet. On the structural origin of the anisotropy in the myocardium: Multiscale modeling and analysis. Journal of the mechanical behavior of biomedical materials, 2022. ⟨hal-03604234⟩
111 Consultations
157 Téléchargements

Partager

Gmail Facebook X LinkedIn More