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Article Dans Une Revue Journal of Infectious Diseases Année : 2022

Malaria in the first trimester of pregnancy and fetal growth: results from a Beninese pre-conceptional cohort

Babagnide Francois Koladjo
  • Fonction : Auteur
Emmanuel Yovo
  • Fonction : Auteur
Manfred Accrombessi
  • Fonction : Auteur
Gino Agbota
  • Fonction : Auteur
William Atade
  • Fonction : Auteur
Olaiitan T. Ladikpo
  • Fonction : Auteur
Murielle Mehoba
  • Fonction : Auteur
Auguste Degbe
  • Fonction : Auteur
Nikki Jackson
  • Fonction : Auteur
Achille Massougbodji
  • Fonction : Auteur
Darius Sossou
  • Fonction : Auteur
Bertin Vianou
  • Fonction : Auteur
Michel Cot
  • Fonction : Auteur
Gilles Cottrell
  • Fonction : Auteur
Nadine Fievet
  • Fonction : Auteur
Jennifer Zeitlin

Résumé

BACKGROUND: Malaria in early pregnancy occurs at a time when the placenta is developing, with possible consequences on placental function and fetal growth. We assessed the association between first trimester malaria and fetal growth documented through repeated ultrasound scans. METHODS: The RECIPAL preconceptional cohort included 411 Beninese pregnant women followed from 7 weeks' gestation (wg) until delivery. Among them, 218 had four scans for fetal monitoring at 16, 22, 28, and 34wg. Multivariate seemingly unrelated regression models were used to assess the association of microscopic malaria in the first trimester (<15wg) with abdominal circumference, head circumference, biparietal diameter and femur length throughout the pregnancy. RESULTS: Of the 39% (86/218) of women with at least one microscopic malarial infection during pregnancy, 52.3% (45/86) were infected in the first trimester. Most women (88.5%) were multiparous. There was no association between adjusted Z-scores for fetal growth parameters and first trimester malaria. Parity, newborn sex, socioeconomic level and maternal BMI significantly influenced fetal growth. CONCLUSIONS: In a context where malaria infections in pregnancy are well detected and treated, their adverse effect on fetal growth may be limited. Our results argue in favour of preventing and treating infections as early as in the first trimester.

Dates et versions

hal-03599254 , version 1 (07-03-2022)

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Citer

Babagnide Francois Koladjo, Emmanuel Yovo, Manfred Accrombessi, Gino Agbota, William Atade, et al.. Malaria in the first trimester of pregnancy and fetal growth: results from a Beninese pre-conceptional cohort. Journal of Infectious Diseases, 2022, ⟨10.1093/infdis/jiac012⟩. ⟨hal-03599254⟩

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