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Article Dans Une Revue Trends in Biochemical Sciences Année : 2021

Nucleic Acid-Based Technologies Targeting Coronaviruses

Résumé

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.

Dates et versions

hal-03599167 , version 1 (06-03-2022)

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Citer

Thi Khanh Le, Clément Paris, Khadija Shahed Khan, Fran Robson, Wai-Lung Ng, et al.. Nucleic Acid-Based Technologies Targeting Coronaviruses. Trends in Biochemical Sciences, 2021, 46 (5), pp.351-365. ⟨10.1016/j.tibs.2020.11.010⟩. ⟨hal-03599167⟩
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