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Communication Dans Un Congrès Année : 2021

Sensitivity Analysis of a Cardio-respiratory Model in Preterm Newborns for the Study of Patent Ductus Arteriosus

Résumé

This paper proposes an integrated model of cardio-respiratory interactions in preterm newborns, focused on the study of the patent ductus arteriosus (PDA). A formal model parameter sensitivity analysis on blood flow through the PDA is performed. Results show that the proposed model is capable of simulating hemodynamics in right-to-left and left-to-right shunts. For both configurations, the most significant parameters are associated with mechanical ventricular properties and circulatory parameters related to left ventricle loading conditions. These results highlight important physiological mechanisms involved in PDA and provide key information towards the definition of patient-specific parameters. © 2021 IEEE.
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Dates et versions

hal-03596049 , version 1 (03-03-2022)

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Citer

O. Duport, Virginie Le Rolle, G. Guerrero, A. Beuchee, A. Hernandez. Sensitivity Analysis of a Cardio-respiratory Model in Preterm Newborns for the Study of Patent Ductus Arteriosus. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021, Nov 2021, Mexico, Mexico. pp.4420-4423, ⟨10.1109/EMBC46164.2021.9630140⟩. ⟨hal-03596049⟩
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