Study and quantification of enantiodiscrimination power of four polymeric chiral LLCs using NAD 2D-NMR - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2022

Study and quantification of enantiodiscrimination power of four polymeric chiral LLCs using NAD 2D-NMR

Résumé

Identifying and understanding the role of key molecular factors involved in the orientation/discrimination phenomena of analytes in polymer-based chiral liquid crystals (CLCs) are essential tasks for optimizing computational predictions (molecular dynamics simulation) of existing orienting systems, as well as designing novel helically chiral polymers as new enantiodiscriminating aligning media. In this perspective, we propose to quantify and compare the enantiodiscrimination power of four homochiral polymer-based lyotropic liquid crystals (LLCs) toward a given chiral solute using its 2H residual quadrupolar couplings (2H-RQCs) measured by anisotropic natural abundance deuterium 2D-NMR (ANAD 2D-NMR). Two families of chiral polymers are investigated in this study: i) the polypeptide polymers (PBLG and PCBLL), ii) the polyacetylene polymers (PDA and L-MSP, a new system never published so far). As model solute, we investigate the case of camphor, an interesting rigid bicyclic chiral molecule possessing ten 2H-RQCs (10 inequivalent monodeurated isotopomers per enantiomer). In order to analyse the orientational behaviour of each enantiomer in a single oriented sample, while simplifying the identification of the (D/L)-isomer signals on spectra, a D-isomer enriched scalemic mixture (ee(D) = 30%) was used. Orientational data of camphor in each mesophase were calculated for the first time with the computer program ConArch+, modified to accept 2H-RQCs as anisotropic data input. Differences in enantiodiscriminations provided by the four aligning systems are examined and discussed in terms of structural and chemical features between polymers. The new L-MSP mesophase described in this work exhibits very promising enantiodiscrimination capacities.
Fichier principal
Vignette du fichier
PCCP 2022 (1).pdf (3.1 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03586878 , version 1 (23-03-2022)

Identifiants

Citer

Philippe Berdagué, Boris Gouilleux, Markus Noll, Stefan Immel, Michael Reggelin, et al.. Study and quantification of enantiodiscrimination power of four polymeric chiral LLCs using NAD 2D-NMR. Physical Chemistry Chemical Physics, 2022, 24 (12), pp.7338-7348. ⟨10.1039/D1CP04915A⟩. ⟨hal-03586878⟩
27 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More