THE REPERTOIRE OF SEIZURE ONSET PATTERNS IN HUMAN FOCAL EPILEPSIES: DETERMINANTS AND PROGNOSTIC - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Epilepsia Année : 2019

THE REPERTOIRE OF SEIZURE ONSET PATTERNS IN HUMAN FOCAL EPILEPSIES: DETERMINANTS AND PROGNOSTIC

Résumé

In this study, we seek to analyze the determinants of the intracranial EEG seizure onset pattern and the impact of the seizure onset pattern in predicting postsurgical seizure outcome. Methods: To this end, we analyzed 820 seizures from 252 consecutive patients explored by SEEG (total of 2148 electrodes) including various forms of focal refractory epilepsies. We used a reproducible method combining visual and time-frequency analyses. Results: We described eight seizure onset patterns: low-voltage fast activity (LVFA), preictal spiking followed by LVFA, burst of poly-spikes followed by LVFA, slow wave/DC shift followed by LVFA, theta/alpha sharp waves, beta sharp waves, rhythmic spikes/spike-waves and delta-brush. LVFA occurred in 79% of patients. The seizureonset pattern was significantly associated with: 1) underlying etiology (burst of polyspikes followed by LVFA with the presence of a focal cortical dysplasia, LVFA with malformation of cortical development, post-vascular and undetermined epilepsies); 2) spatial organization of the epileptogenic zone (burst of poly-spikes followed by LVFA with focal organization, slow wave/DC shift followed by LVFA with network organization); 3) post-surgical seizure outcome (better outcome when LVFA present). Significance: This study demonstrates that the main determinants of the seizure onset pattern are the underlying etiology and the spatial organization of the epileptogenic zone. Concerning the post-surgical seizure outcome, the main determinant factor is the spatial organization of the epileptogenic zone, but the seizure onset pattern plays also a role, conferring better prognosis when LVFA was present.
Fichier principal
Vignette du fichier
SOP repertoire in SEEG_R2.pdf (733.72 Ko) Télécharger le fichier
SOP repertoire in SEEG_Figure 1_revised.tif (2.5 Mo) Télécharger le fichier
SOP repertoire in SEEG_Figure 2_revised.tif (890.29 Ko) Télécharger le fichier
SOP repertoire in SEEG_Figure 3_revised.tif (649.49 Ko) Télécharger le fichier
SOP repertoire in SEEG_Figure 4_revised.tif (518.32 Ko) Télécharger le fichier
SOP repertoire in SEEG_Figure 5_revised.tif (477.7 Ko) Télécharger le fichier
SOP repertoire in SEEG_Figure 6.tif (653.39 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03583590 , version 1 (21-02-2022)

Identifiants

Citer

Stanislas Lagarde, Sinziana Buzori, Agnès Trebuchon, Romain Carron, Didier Scavarda, et al.. THE REPERTOIRE OF SEIZURE ONSET PATTERNS IN HUMAN FOCAL EPILEPSIES: DETERMINANTS AND PROGNOSTIC. Epilepsia, 2019, 60 (1), pp.85-95. ⟨10.1111/epi.14604⟩. ⟨hal-03583590⟩
43 Consultations
69 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More