Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of diabetes science and technology Année : 2023

Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling

Résumé

Background: Intraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient.Methods: Relying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC.Results: Intraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma.Conclusion: Intraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual-not actual-transit space for insulin delivery.

Dates et versions

hal-03577687 , version 1 (16-02-2022)

Identifiants

Citer

Jorge Lo Presti, Alfonso Galderisi, Francis Doyle, Howard Zisser, Eyal Dassau, et al.. Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling. Journal of diabetes science and technology, 2023, 17 (3), pp.751-756. ⟨10.1177/19322968221076559⟩. ⟨hal-03577687⟩
50 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More