Total Syntheses and In Vivo Quantitation of Novel Neurofuran and Dihomo-isofuran Derived from Docosahexaenoic Acid and Adrenic Acid - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2015

Total Syntheses and In Vivo Quantitation of Novel Neurofuran and Dihomo-isofuran Derived from Docosahexaenoic Acid and Adrenic Acid

Résumé

Neurofurans (NeuroFs) and dihomo-isofurans (dihomo-IsoFs) are produced in vivo by non-enzymatic free-radical pathways from docosahexaenoic and adrenic acids, respectively. As these metabolites are produced in minute amounts, their analyses in biological samples remain challenging. Syntheses of neurofuran and dihomo-isofurans described are based on a pivotal strategy, thanks to an enantiomerically enriched intermediate, which allowed, for the first time, access to both families: the alkenyl and enediol. Owing to this formation, quantitation of specific NeuroF and dihomo-IsoFs in biological samples was attainable.

Domaines

Chimie

Dates et versions

hal-03576544 , version 1 (16-02-2022)

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Citer

Aurélien de La Torre, Yiu Yiu Lee, Attilio Mazzoni, Alexandre Guy, Valérie Bultel-Poncé, et al.. Total Syntheses and In Vivo Quantitation of Novel Neurofuran and Dihomo-isofuran Derived from Docosahexaenoic Acid and Adrenic Acid. Chemistry - A European Journal, 2015, 21 (6), pp.2442-2446. ⟨10.1002/chem.201405497⟩. ⟨hal-03576544⟩
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