The global exploring feature of the surrogate model makes it a useful intermedia for design optimization. The accuracy of the surrogate model is closely related with the efficiency of optima-search. The cokriging approach described in present studies can significantly improve the surrogate model accuracy and cut down the turnaround time spent on the modeling process. Compared to the universal Kriging method, the cokriging method interpolates not only the sampling data, but also on their associated derivatives. However, the derivatives, especially high order ones, are too computationally costly to be easily affordable, forming a bottleneck for the application of derivative enhanced methods. Based on the sensitivity analysis of Navier–Stokes equations, current study introduces a low-cost method to compute the high-order derivatives, making high order derivatives enhanced cokriging modeling practically achievable. For a methodological illustration, second-order derivatives of regression model and correlation models are proposed. A second-order derivative enhanced cokriging model-based optimization tool was developed and tested on the optimal design of an automotive engine cooling fan. This approach improves the modern optimal design efficiency and proposes a novel direction for the large scale optimization problems