Fullerene‐<span style="font-variant:small-caps;">C<sub>60</sub></span>/<span style="font-variant:small-caps;">NH<sub>2</sub></span>: A recyclable heterogeneous catalyst for the green synthesis of chromene and pyrimidine derivatives and antibacterial evaluation - Archive ouverte HAL Access content directly
Journal Articles Journal of Heterocyclic Chemistry Year : 2022

Fullerene‐C60/NH2: A recyclable heterogeneous catalyst for the green synthesis of chromene and pyrimidine derivatives and antibacterial evaluation

Abstract

An effective procedure for the synthesis of amino-functionalized fullerene with diethylenetriamine (C60-NH2) is described. The obtained material was characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), elemental analysis (CHN), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). The catalytic activity of C60-NH2 was studied in multicomponent reactions (MCRs) for the synthesis of chromene and pyrimidine derivatives. The results revealed that C60-NH2 was very effective and the desired chromene and pyrimidine products were isolated in good to excellent yields 78–97% and 81-98%, respectively. Moreover, the C60-NH2 catalyst could be recycled and reused for at least 8 runs without substantial loss in its activity, which makes our procedure environmentally benign. Antibacterial behavior of some of the synthesized products was studied for Gram-positive and Gram-negative bacteria using disk and well diffusion methods. The chromene 4g showed a good antibacterial activity against both bacterial strains Staphylococcus aureus (S. aureus) and Serratia marcescens (S. marcescens). A good antibacterial activity was also detected for chromene 4o and pyrimidine 7j against S. aureus. The chromene 4m, 4n and pyrimidine 7i compounds displayed a good activity against Micrococcus luteus (M. luteus) as a Gram-positive bacterium.
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Dates and versions

hal-03554736 , version 1 (03-02-2022)

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Maryam M. Mirza‐Aghayan, Marzieh Mohammadi, Rabah Boukherroub. Fullerene‐C60/NH2: A recyclable heterogeneous catalyst for the green synthesis of chromene and pyrimidine derivatives and antibacterial evaluation. Journal of Heterocyclic Chemistry, 2022, 49 (6), pp.1102-1115. ⟨10.1002/jhet.4453⟩. ⟨hal-03554736⟩
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