Meningococcal disease: A paradigm of type‐IV pilus dependent pathogenesis - Archive ouverte HAL
Journal Articles Cellular Microbiology Year : 2020

Meningococcal disease: A paradigm of type‐IV pilus dependent pathogenesis

Mathieu Coureuil
Isabel dos Santos Souza
  • Function : Author
Nawal Maïssa
  • Function : Author
Jason Ziveri
  • Function : Author
Philippe C Morand
  • Function : Author
Xavier Nassif
Sandrine Bourdoulous

Abstract

Neisseria meningitidis (meningococcus) is a Gram-negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. This review summarises 20 years of research on meningococcal type IV pilus-dependent virulence mechanisms, up to the identification of promising antivirulence compounds that target type IV pili.

Dates and versions

hal-03552862 , version 1 (15-02-2022)

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Mathieu Coureuil, Isabel dos Santos Souza, Nawal Maïssa, Jason Ziveri, Philippe C Morand, et al.. Meningococcal disease: A paradigm of type‐IV pilus dependent pathogenesis. Cellular Microbiology, 2020, 22 (4), ⟨10.1111/cmi.13185⟩. ⟨hal-03552862⟩
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