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Article Dans Une Revue Chemical Communications Année : 2018

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

Giuseppina de Simone
Andrea Angeli
Murat Bozdag
Claudiu Supuran
Simona Maria Monti
Vincenzo Alterio

Résumé

N-Unsubstituted carbamates have scarcely been investigated so far as carbonic anhydrase inhibitors (CAIs). By means of kinetic and structural studies, in this paper we demonstrate that such molecules can effectively inhibit hCAs and can be used as lead compounds for the development of CAIs possessing a binding mode similar to one of the CA substrates, bicarbonate.

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Chimie
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Dates et versions

hal-03551584 , version 1 (01-02-2022)

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Citer

Giuseppina de Simone, Andrea Angeli, Murat Bozdag, Claudiu Supuran, Jean-Yves Winum, et al.. Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding. Chemical Communications, 2018, 54 (73), pp.10312-10315. ⟨10.1039/c8cc05755a⟩. ⟨hal-03551584⟩
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