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Article Dans Une Revue Chemical Communications Année : 2016

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

Résumé

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.

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Chimie
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Dates et versions

hal-03549186 , version 1 (31-01-2022)

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Vincenzo Alterio, Roberta Cadoni, Davide Esposito, Daniela Vullo, Anna Di Fiore, et al.. Benzoxaborole as a new chemotype for carbonic anhydrase inhibition. Chemical Communications, 2016, 52 (80), pp.11983-11986. ⟨10.1039/c6cc06399c⟩. ⟨hal-03549186⟩
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