Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
Résumé
Mas-related G-protein-coupled receptor X1 (MrgprX1) is a human-specific Mrgpr and its expression is restricted to primary sensory neurons. However, its role in nociception and pain signaling pathways is largely unknown. This study aims to investigate a role for MrgprX1 in nociception via interaction with the pain receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), using in-vitro and in-vivo human neuronal models. MrgprX1 protein expression in human trigeminal nociceptors was investigated
Domaines
Sciences du Vivant [q-bio]
Fichier principal
McMillan et al. - 2021 - Endogenous Mas‐related G‐protein‐coupled receptor .pdf (1.53 Mo)
Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte