Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves - Archive ouverte HAL Access content directly
Journal Articles FASEB Journal Year : 2021

Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves

Hayley Mcmillan
  • Function : Author
Fionnuala Lundy
Orla Dunne
Banan Al‐natour
  • Function : Author
Charlotte Jeanneau
  • Function : Author
Tim M Curtis
Ikhlas El Karim

Abstract

Mas-related G-protein-coupled receptor X1 (MrgprX1) is a human-specific Mrgpr and its expression is restricted to primary sensory neurons. However, its role in nociception and pain signaling pathways is largely unknown. This study aims to investigate a role for MrgprX1 in nociception via interaction with the pain receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), using in-vitro and in-vivo human neuronal models. MrgprX1 protein expression in human trigeminal nociceptors was investigated
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Dates and versions

hal-03547537 , version 1 (28-01-2022)

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Hayley Mcmillan, Fionnuala Lundy, Orla Dunne, Banan Al‐natour, Charlotte Jeanneau, et al.. Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves. FASEB Journal, 2021, 35 (5), ⟨10.1096/fj.202001667RR⟩. ⟨hal-03547537⟩
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