Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2022

Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease

Résumé

Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of CuII(Amyloid-β) interaction. Their ability to remove CuII from CuII(Amyloid-β), to stop CuII(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of CuII(Amyloid-β) was shown.
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Dates et versions

hal-03547481 , version 1 (28-01-2022)

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Elena Atrián-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, et al.. Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease. Chemical Communications, 2022, 58 (14), pp.2367-2370. ⟨10.1039/D1CC05792H⟩. ⟨hal-03547481⟩
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