Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease
Résumé
Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of CuII(Amyloid-β) interaction. Their ability to remove CuII from CuII(Amyloid-β), to stop CuII(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of CuII(Amyloid-β) was shown.
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Atrian-Blasco, Keggin-type, 2022.pdf (976.94 Ko)
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SI_Atrian-Blasco, Keggin-type, 2022.pdf (1.51 Mo)
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