Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors
Résumé
Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-
binding groups (ZBGs), has been investigated as a carbonic anhydrase
inhibitor (CAI) by means of kinetic, crystallographic and Raman
spectroscopy studies, highlighting interesting results on its mecha-
nism of action. These data can be exploited to design new, effective
and selective CAIs.