A Novel Method for In Vitro 3D Imaging of Dissecting Pressurized Arterial Segments Using X-Ray Microtomography - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Experimental Mechanics Année : 2020

A Novel Method for In Vitro 3D Imaging of Dissecting Pressurized Arterial Segments Using X-Ray Microtomography

J Brunet
B Pierrat
  • Fonction : Auteur
N Curt
  • Fonction : Auteur
P Badel
  • Fonction : Auteur

Résumé

Background: It is commonly admitted that a dissection initiates with an intimal tear or at least a defect inside the arterial wall. Nevertheless, few studies investigated the initiation sequence due to the difficulty to monitor this process. Objective: The objective of this work was to observe and investigate the mechanisms leading an intimal tear to propagate into a dissection. Methods: A custom-made tension-inflation device fitting inside an X-ray microtomography setup was designed. A notch was created inside a porcine carotid artery before performing the tension-inflation test. The X-ray tomography setup allowed observing the wall-structure and the notch behavior during the inflation of the carotid artery. Results: A quantitative description of the notch morphology was performed, suggesting the prevalence of high shear stress in the region of the crack tip as a possible trigger for propagation of a dissection. Conclusions: The present experimental approach allowed understanding better the mechanisms leading to dissection and constitutes a first step toward the improvement of failure modeling and risk assessment of this disease.
Fichier principal
Vignette du fichier
Brunet2021_Article_ANovelMethodForInVitro3DImagin.pdf (1.84 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03544159 , version 1 (26-01-2022)

Identifiants

Citer

J Brunet, B Pierrat, Jérôme Adrien, E Maire, N Curt, et al.. A Novel Method for In Vitro 3D Imaging of Dissecting Pressurized Arterial Segments Using X-Ray Microtomography. Experimental Mechanics, 2020, 61, pp.147 - 157. ⟨10.1007/s11340-020-00645-x⟩. ⟨hal-03544159⟩
11 Consultations
13 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More