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Article Dans Une Revue Journal of Chromatography A Année : 2015

Size-based characterization of nanoparticle mixtures by the inline coupling of capillary electrophoresis to Taylor dispersion analysis

Résumé

Separation of closely related nanoparticles is still a challenging issue for the characterization of complex mixtures for industrial/research applications or regulatory purposes. In this work, the remarkable separating performances of CE were complemented with the absolute size-based determination provided by Taylor dispersion analysis (TDA) for the characterization of nanoparticle mixtures. The inline hyphenation of CE to TDA was successfully implemented for the baseline separation followed by a size-based characterization of a bimodal mixture containing two closely size-related nanolatexes (70nm and 56nm radii). A pixel sensor UV area imager providing three detection points along the capillary was used for a differential measurement of the peak broadening during the Taylor dispersion step. Comparison of this new technique with dynamic light scattering and hydrodynamic chromatography is also discussed.
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Dates et versions

hal-03541142 , version 1 (24-01-2022)

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Farid Oukacine, Aurélie Morel, Isabelle Desvignes, Herve Cottet. Size-based characterization of nanoparticle mixtures by the inline coupling of capillary electrophoresis to Taylor dispersion analysis. Journal of Chromatography A, 2015, 1426, pp.220-225. ⟨10.1016/j.chroma.2015.11.024⟩. ⟨hal-03541142⟩
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