The product design project is a complex problem because objectives and constraints must be considered simultaneously, the sustainability context is highly relevant and specific, decision-making involves not only customer needs but also of other stakeholders, especially the organization in which the design project takes place. This work presents a systematic literature review of design methodologies for chemical products to identify how that problem has been addressed and which are the future challenges to be met. The review involved the analysis of 262 research papers and 336 patents, classified according to the chemical product type, the design phase studied, and whether they consider association with a business context. The study highlights the need for holistic product design methodologies applicable from the early design stages, covering the assessment of customer needs and the requirements of other stakeholders, as well as the business context where the design process is carried out.