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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2009

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

Résumé

Within the frame of the design of prodrug candidates to deliver a C-alkylamidine antimalarial agent, we showed that specific O-substitutions were needed on the alkylamidoxime structure. Among the newly synthesized molecules, bis-oxadiazolone and bis-O-methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration.

Dates et versions

hal-03530218 , version 1 (17-01-2022)

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Mahama Ouattara, Sharon Wein, Séverine Denoyelle, Stéphanie Ortial, Thierry Durand, et al.. Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.624-626. ⟨10.1016/j.bmcl.2008.12.058⟩. ⟨hal-03530218⟩
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