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Article Dans Une Revue BMC Medicine Année : 2021

Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

1 IACR - International Agency for Cancer Research
2 University of Oxford
3 Aarhus University [Aarhus]
4 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
5 UCPH - University of Copenhagen = Københavns Universitet
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
8 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
9 GIHNP-R - German Institute of Human Nutrition Potsdam-Rehbruecke [Nuthetal, Germany]
10 University of Potsdam = Universität Potsdam
11 ISPRO - Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
12 IRCCS Istituto Nazionale dei Tumori [Milano]
13 University of Naples Federico II = Università degli studi di Napoli Federico II
14 ASP 7 - Provincial Health Authority = Azienda Sanitaria Provinciale [Ragusa]
15 UNITO - Università degli studi di Torino = University of Turin
16 RIVM - National Institute for Public Health and the Environment [Bilthoven]
17 UMCU - University Medical Center [Utrecht]
18 UiT - The Arctic University of Norway [Tromsø, Norway]
19 ICO - Catalan Institute of Oncology = Instituto Catalán de Oncología
20 L’Hospitalet de Llobregat [Barcelona, Spain]
21 EASP - Escuela Andaluza de Salud Pública [Granada, Spain]
22 UGR - Universidad de Granada = University of Granada
23 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
24 Public Health Division of Gipuzkoa, Basque Government, CIBER en Salud Pública
25 IIS Biodonostia - Biodonostia Health Research Institute [Donostia-San Sebastian, Spain]
26 Murcia Regional Health Council [Murcia]
27 Universidad de Antioquia = University of Antioquia [Medellín, Colombia]
28 Navarra Public Health Institute
29 Umeå University, Sweden
30 Imperial College London
Marc J.R. Gunter
  • Fonction : Auteur

Résumé

Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2). Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786). Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed. Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.
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hal-03524592 , version 1 (02-06-2022)

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Mathilde His, Vivian Viallon, Laure Dossus, Julie A. Schmidt, Ruth C. Travis, et al.. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort. BMC Medicine, 2021, 19, pp.312. ⟨10.1186/s12916-021-02183-2⟩. ⟨hal-03524592⟩
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