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Article Dans Une Revue Histopathology Année : 2022

Cutaneous histiocytoses in children

Résumé

Cutaneous histiocytoses constitute a heterogeneous group of diseases characterised by the cutaneous accumulation of cells with the cytological and phenotypic features of macrophages or dendritic cells. The clinical spectrum ranges from self-resolving, skin-limited conditions to severe, multiorgan disease with a high morbidity rate. Until recently, cutaneous histiocytoses were classified according to the immunophenotype of the pathological cells, with differentiation between Langerhans cell histiocytosis (LCH) [CD1a+, CD207 (langerin)+] and non-Langerhans cell histiocytosis (CD68+, CD163+, CD1a−, CD207−). Over the last 12 years, a number of new pathophysiological findings (in particular, molecular pathology results) regarding histiocytoses have contributed to a new classification based on molecular alterations, as well as on clinical and imaging characteristics and the phenotype. The most frequent entities in children are juvenile xanthogranuloma and LCH.

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Cancer
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Dates et versions

hal-03524493 , version 1 (13-01-2022)

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Sylvie R. Fraitag, Jean François J.F. Emile. Cutaneous histiocytoses in children. Histopathology, 2022, 80 (1), pp.196-215. ⟨10.1111/his.14569⟩. ⟨hal-03524493⟩
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