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Article Dans Une Revue The Plant cell Année : 2021

Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway

Pengliang Wei
Manon Demulder
Thomas Eekhout
Kaoru Okamoto Yoshiyama
Long Nguyen
Ilse Vercauteren
Margot Galle
Geert de Jaeger
Paul Larsen
Remy Loris
Lieven de Veylder

Résumé

Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic and mutually enhancing stresses that profoundly affect crop yield. Both stresses strongly inhibit root growth, resulting from a progressive exhaustion of the stem cell niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability to maintain a functional root stem cell niche in Arabidopsis thaliana under Al toxic conditions. CK2 operates through phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA RADIATION1 (SOG1), priming its activity under DNA-damaging conditions. In addition to yielding Al tolerance, CK2 and SOG1 inactivation prevents meristem exhaustion under Pi starvation, revealing the existence of a low Pi-induced cell cycle checkpoint that depends on the DNA damage activator ATAXIA-TELANGIECTASIA MUTATED (ATM). Overall, our data reveal an important physiological role for the plant DNA damage response pathway under agriculturally limiting growth conditions, opening new avenues to cope with Pi limitation.

Dates et versions

hal-03521799 , version 1 (11-01-2022)

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Citer

Pengliang Wei, Manon Demulder, Pascale David, Thomas Eekhout, Kaoru Okamoto Yoshiyama, et al.. Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. The Plant cell, 2021, 33 (4), pp.1361-1380. ⟨10.1093/plcell/koab005⟩. ⟨hal-03521799⟩
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