Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Evolution, Medicine, and Public Health Année : 2021

Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists

India Schneider-Crease
  • Fonction : Auteur
Aaron D. Blackwell
  • Fonction : Auteur
Thomas S. Kraft
  • Fonction : Auteur
Melissa Emery Thompson
  • Fonction : Auteur
Ivan Maldonado Suarez
  • Fonction : Auteur
Daniel Cummings
  • Fonction : Auteur
Noah Snyder-Mackler
  • Fonction : Auteur
Michael Gurven
Hillard Kaplan
  • Fonction : Auteur
Benjamin C. Trumble
  • Fonction : Auteur

Résumé

Background: Soil-transmitted helminths (STHs) and humans share long co-evolutionary histories over which STHs have evolved strategies to permit their persistence by downregulating host immunity. Understanding the interactions between STHs and other pathogens can inform our understanding of human evolution and contemporary disease patterns. Methodology: We worked with Tsimane forager-horticulturalists in the Bolivian Amazon, where STHs are prevalent. We tested whether STHs and eosinophil levels—likely indicative of infection in this population—are associated with dampened immune responses to in vitro stimulation with H1N1 and lipopolysaccharide (LPS) antigens. Whole blood samples (n ¼179) were treated with H1N1 vaccine and LPS and assayed for 13 cytokines (INF-c, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, GM-CSF and TNF-A). We eval-uated how STHs and eosinophil levels affected cytokine responses and T helper (Th) 1 and Th2-cytokine suite responses to stimulation. Results: Infection with Ascaris lumbricoides was significantly (P 0.05) associated with lower response of some cytokines to H1N1 and LPS in women. Eosinophils were significantly negatively associated with some cytokine responses to H1N1 and LPS, with the strongest effects in women, and associated with a reduced Th1- and Th2-cytokine response to H1N1 and LPS in women and men. Conclusions and implications: Consistent with the ‘old friends’ and hygiene hypotheses, we find that STHs were associated with dampened cytokine responses to certain viral and bacterial antigens. This suggests that STH infections may play an essential role in immune response regulation and that the lack of STH immune priming in industrialized populations may increase the risk of over-reactive im-munity. Lay Summary: Indicators of helminth infection were associated with dampened cytokine immune responses to in vitro stimulation with viral and bacterial antigens in Tsimane forager-horticulturalists in the Bolivian Amazon, consistent with the ‘old friends’ and hygiene hypotheses.

Dates et versions

hal-03521427 , version 1 (11-01-2022)

Licence

Paternité

Identifiants

Citer

India Schneider-Crease, Aaron D. Blackwell, Thomas S. Kraft, Melissa Emery Thompson, Ivan Maldonado Suarez, et al.. Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists. Evolution, Medicine, and Public Health, 2021, 9 (1), pp.349-359. ⟨10.1093/emph/eoab035⟩. ⟨hal-03521427⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More