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Article Dans Une Revue American Journal of Bioinformatics and Computational Biology Année : 2013

Designing a Peptide-dendrimer for Use as a Synthetic Vaccine Against Plasmodium falciparum

Résumé

This work presents anew computational analysis using post-genomic data in order to design a new vaccine candidate against Plasmodium falciparum, a parasite responsible for malaria. It is based on a poly(amidoamine) (PAMAM) eight-branched dendrimeric structure integrating B cell epitopes. To do so, all available experimental epitopes were identified, either stored in databases or bibliographic references, and analysed by means of bioinformatic-tools for obtaining consensus epitopes up to six amino acids in length. An eight-branched tertiary structure integrating the consensus epitopes is proposed using a molecular mechanics tool. This computational technique could also be applied to other infectious agents as well as tumour antigens.
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Dates et versions

hal-03521081 , version 1 (11-01-2022)

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Raúl Isea, Johan Hoebeke, Rafael Mayo-García. Designing a Peptide-dendrimer for Use as a Synthetic Vaccine Against Plasmodium falciparum. American Journal of Bioinformatics and Computational Biology, 2013, 1, pp.1-8. ⟨10.7726/ajbcb.2013.1001⟩. ⟨hal-03521081⟩
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