Designing a Peptide-dendrimer for Use as a Synthetic Vaccine Against Plasmodium falciparum
Résumé
This work presents anew computational analysis using post-genomic data in order to design a new vaccine candidate against Plasmodium falciparum, a parasite responsible for malaria. It is based on a poly(amidoamine) (PAMAM) eight-branched dendrimeric structure integrating B cell epitopes. To do so, all available experimental epitopes were identified, either stored in databases or bibliographic references, and analysed by means of bioinformatic-tools for obtaining consensus epitopes up to six amino acids in length. An eight-branched tertiary structure integrating the consensus epitopes is proposed using a molecular mechanics tool. This computational technique could also be applied to other infectious agents as well as tumour antigens.
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