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Article Dans Une Revue PLoS Neglected Tropical Diseases Année : 2021

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

Stéphanie Caby
Wolfgang Sippl
Raymond J Pierce
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Résumé

Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has elicited considerable interest as a target for drug discovery. Invalidation of its transcripts by RNAi leads to impaired survival of the worms in infected mice and its inhibition causes cell apoptosis and death. To determine why it is a promising therapeutic target the study of the currently unknown cellular signaling pathways involving this enzyme is essential. Protein partners of SmHDAC8 were previously identified by yeast two-hybrid (Y2H) cDNA library screening and by mass spectrometry (MS) analysis. Among these partners we characterized SmRho1, the schistosome orthologue of human RhoA GTPase, which is involved in the regulation of the cytoskeleton. In this work, we validated the interaction between SmHDAC8 and SmRho1 and explored the role of the lysine deacetylase in cytoskeletal regulation.

Domaines

Biologie animale
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Dates et versions

hal-03503639 , version 1 (28-12-2021)

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Lucile Pagliazzo, Stéphanie Caby, Julien Lancelot, Sophie Salomé-Desnoulez, Jean-Michel Saliou, et al.. Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni. PLoS Neglected Tropical Diseases, 2021, 15 (11), pp.e0009503. ⟨10.1371/journal.pntd.0009503⟩. ⟨hal-03503639⟩
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