Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound
Résumé
Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13–6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%–27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of the this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound–microbubble interaction hypothesis.
Domaines
Acoustique [physics.class-ph]
Fichier principal
Carlson+et+al_2021_Jpn._J._Appl._Phys._10.35848_1347-4065_ac467f.pdf (3.08 Mo)
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