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Article Dans Une Revue Japanese Journal of Applied Physics Année : 2022

Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Résumé

Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13–6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%–27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of the this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound–microbubble interaction hypothesis.
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Dates et versions

hal-03503073 , version 1 (28-12-2021)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Craig Stuart Carlson, Nicole Anderton, Antje Pohl, Andrew John Smith, Nobuki Kudo, et al.. Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound. Japanese Journal of Applied Physics, 2022, Ultrasonic Electronics, 61 (SG), pp.SG1030. ⟨10.35848/1347-4065/ac467f⟩. ⟨hal-03503073⟩
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