How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe - Archive ouverte HAL Access content directly
Journal Articles Intrinsically Disordered Proteins Year : 2016

How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe

Philippe Lieutaud
François Ferron
Alexey V Uversky
  • Function : Author
  • PersonId : 1121057
Lukasz Kurgan
  • Function : Author
  • PersonId : 1121058
Vladimir N Uversky

Abstract

In the last 2 decades it has become increasingly evident that a large number of proteins are either fully or partially disordered. Intrinsically disordered proteins lack a stable 3D structure, are ubiquitous and fulfill essential biological functions. Their conformational heterogeneity is encoded in their amino acid sequences, thereby allowing intrinsically disordered proteins or regions to be recognized based on properties of these sequences. The identification of disordered regions facilitates the functional annotation of proteins and is instrumental for delineating boundaries of protein domains amenable to structural determination with X-ray crystallization. This article discusses a comprehensive selection of databases and methods currently employed to disseminate experimental and putative annotations of disorder, predict disorder and identify regions involved in induced folding. It also provides a set of detailed instructions that should be followed to perform computational analysis of disorder.
Fichier principal
Vignette du fichier
Lieutaud_IDPs_Revised-VF.pdf (1.09 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03499972 , version 1 (06-01-2022)

Identifiers

Cite

Philippe Lieutaud, François Ferron, Alexey V Uversky, Lukasz Kurgan, Vladimir N Uversky, et al.. How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe. Intrinsically Disordered Proteins, 2016, 4 (1), pp.e1259708. ⟨10.1080/21690707.2016.1259708⟩. ⟨hal-03499972⟩
42 View
171 Download

Altmetric

Share

Gmail Facebook X LinkedIn More