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Article Dans Une Revue International Journal of Pharmaceutics Année : 2020

Controlled delivery of follicle-stimulating hormone in cattle

Elias Fattal
Marinette Moreau
  • Fonction : Auteur
Elodie Lego
  • Fonction : Auteur
Amélie Bochot
  • Fonction : Auteur correspondant

Résumé

Embryo transfer in cattle is a key issue requiring in vivo production of several mature follicles as opposed to the normal production of only one. In vivo produced embryos can then be transferred to recipient cows for gestation to occur. To obtain a large number of transferable embryos, the superovulation step is crucial. To allow the growth of ovarian follicles, the most commonly used protocol consists of 2 intramuscular injections per day over 4 days of a saline solution of the follicle-stimulating hormone. To reduce workload, technical errors in the injected dose and animal stress, different strategies have been investigated to sustain the release of this hormone over 4 days in 1 or 2 injections. This review introduces the physicochemical properties of the follicle-stimulating hormone and discusses the limitations of marketed products and all the research that has been conducted to overcome these limitations. In particular, the field of subcutaneous administrations, the development of new formulations such as viscous solutions, implants and microspheres and the modification of the structure of the follicle-stimulating hormone are overviewed and discussed.
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Dates et versions

hal-03493591 , version 1 (17-10-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Quentin Deguettes, Elias Fattal, Marinette Moreau, Elodie Lego, Amélie Bochot. Controlled delivery of follicle-stimulating hormone in cattle. International Journal of Pharmaceutics, 2020, 590, pp.119904 -. ⟨10.1016/j.ijpharm.2020.119904⟩. ⟨hal-03493591⟩
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