Glued in lipids: Lipointoxication in cystic fibrosis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue EBioMedicine Année : 2020

Glued in lipids: Lipointoxication in cystic fibrosis

Résumé

Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane regulator (CFTR) gene, which encodes a chloride channel located at the apical surface of epithelial cells. Unsaturated Fatty Acid (UFA) deficiency has been a persistent observation in tissues from patients with CF. However, the impacts of such deficiencies on the etiology of the disease have been the object of intense debates. The aim of the present review is first to highlight the general consensus on fatty acid dysregulations that emerges from, sometimes apparently contradictory, studies. In a second step, a unifying mechanism for the potential impacts of these fatty acid dysregulations in CF cells, based on alterations of membrane biophysical properties (known as lipointoxication), is proposed. Finally, the contribution of lipointoxication to the progression of the CF disease and how it could affect the efficacy of current treatments is also discussed.
Fichier principal
Vignette du fichier
S235239642030414X.pdf (1.53 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-03493275 , version 1 (17-10-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Clarisse Vandebrouck, Thierry Ferreira. Glued in lipids: Lipointoxication in cystic fibrosis. EBioMedicine, 2020, 61, pp.103038 -. ⟨10.1016/j.ebiom.2020.103038⟩. ⟨hal-03493275⟩
19 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More