Fluorogenic probes based on polycyclic sydnone scaffolds
Résumé
We report the synthesis, photophysical characterization and kinetics of a series of polycyclic sydnone derivatives as a potential new class of fluorogenic clickable reagents. After strain-promoted cycloaddition with cyclooctyne BCN, the fluorescence generated by pyrazole products displayed up-to 115-fold fluorescence enhancement compared to reactants. These preliminary results are of interest for possible future applications in bioorthogonal chemistry.
Domaines
Chimie
Origine : Fichiers produits par l'(les) auteur(s)