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Article Dans Une Revue Journal of The American Academy of Dermatology Année : 2020

Deep cutaneous fungal infections in solid-organ transplant recipients

Résumé

BackgroundDeep cutaneous fungal infections (DCFIs) are varied in immunosuppressed patients, with few data for such infections in solid-organ transplant recipients (s-OTRs).ObjectiveTo determine DCFI diagnostic characteristics and outcome with treatments in s-OTRs.MethodsA 20-year retrospective observational study in France was conducted in 8 primary dermatology-dedicated centers for s-OTRs diagnosed with DCFIs. Relevant clinical data on transplants, fungal species, treatments, and outcomes were analyzed.ResultsOverall, 46 s-OTRs developed DCFIs (median delay, 13 months after transplant) with predominant phaeohyphomycoses (46%). Distribution of nodular lesions on limbs and granulomatous findings on histopathology were helpful diagnostic clues. Treatments received were systemic antifungal therapies (48%), systemic antifungal therapies combined with surgery (28%), surgery alone (15%), and modulation of immunosuppression (61%), leading to complete response in 63% of s-OTRs.LimitationsDue to the retrospective observational design of the study.ConclusionsPhaeohyphomycoses are the most common DCFIs in s-OTRs. Multidisciplinary teams are helpful for optimal diagnosis and management.
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hal-03492502 , version 1 (18-07-2022)

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Agnès Galezowski, Julie Delyon, Laurence Le Cleach, Sarah Guégan, Emilie Ducroux, et al.. Deep cutaneous fungal infections in solid-organ transplant recipients. Journal of The American Academy of Dermatology, 2020, 83 (2), pp.455 - 462. ⟨10.1016/j.jaad.2019.12.064⟩. ⟨hal-03492502⟩
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